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Herzzentrum Berlin

New publication: Pulmonary artery augmentation using decellularized equine pericardium (Matrix Patch™)

The group around Prof. Dr. Joachim Photiadis from the German Heart Center, Berlin, Germany, published a paper about their experience with the Matrix Patch equine for the augmentation of branch pulmonary arteries.

Murin P, Weixler VHM, Kuschnerus K, Romanchenko O, Lorenzen V, Nordmeyer J, Cho MY, Sigler M, Photiadis J. Pulmonary artery augmentation using decellularized equine pericardium (Matrix Patch™): initial single-centre experience. Eur J Cardiothorac Surg. 2021ezab183.

Abstract

Objectives:  The aim of this study was to report our initial experience when using Matrix Patch™ a cell-free equine-derived pericardium for the augmentation of branch pulmonary arteries (PAs) in children.

Methods:  Between September 2016 and September 2019, Matrix Patch was used for the augmentation of branch PAs in 96 patients and implanted in 147 separate locations. The median age at implantation was 3.2 years (interquartile range: 0.9-8.4), and 33% of patients were infants. The patch was used mainly in redo surgeries (89.6%). Intra-procedural feasibility and reinterventions were analysed. Primary end points were death or patch-related reoperation/stent implantation. Explanted patches were stained for recellularization/calcification, or to reveal proliferation/inflammation.

Results:  A total of 81 patients, who received patches in 119 separate locations, were followed within a median of 20 months (interquartile range: 10.2-30.2). Patients with early reoperation/stent implantation were excluded from follow-up. No patch-related death was noted. Survival at last follow-up was 88% (95% CI: 78.8-93.7%). Overall probability of freedom from reoperation/stent implantation per location, 12 and 24 months after initial surgery was 85.8% (95% CI: 76.2-91.7%) and 78.7 (95% CI: 65.9-87.2%), respectively. At 20 months, superficial proliferation with discrete macrophage activity was seen in explants; however, no signs of calcification are observed.

Conclusions:  The initial experience with the Matrix Patch in PAs showed comparable results to other xenogeneic patch materials. Long-term follow-up data are needed to prove the desired durability of the patch in different locations.